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ea0019p292 | Reproduction | SFEBES2009

The influence of changes in macronutrient intake during gestation on gene expression of on glucocorticoid receptor (GR) and 11-beta-hydroxysteroid dehydrogenase 1 and 2 (11βhsd1 and 2) in the livers of neonatal pigs; effect of size at birth

Almond K , Lomax M , Bikker P , Symonds M , Mostyn A

Background: Altering maternal nutrition affects fetal development, potentially predisposing them to later metabolic disease. Tissue sensitivity to cortisol is regulated, in part, by GR and 11βhsd1 and 2, and GR and 11βhsd1 expression is known to be raised both with obesity and type 2 diabetes.Objectives: To examine whether gestational diet influences GR and11βhsd1 and 2 mRNA expression in the neonatal liver.Methods: ...

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ea0009p22 | Diabetes and metabolism | BES2005

The effect of a high fat, high cholesterol diet on blood glucose in pigs

Massey K , Laws J , Perkins K , Beattles S , Filby L , Hatton E , Lomax M , Haskard D , Buckingham J , Jarvelin M , Corson A , Lean J , Clarke L

Epidemiological studies have suggested that in man low birth weight followed by rapid catch-up growth dramatically increase the risk of adulthood diabetes and metabolic syndrome. This experiment investigated the effect of a high fat, high cholesterol post-weaning diet on blood glucose levels of low (L) and normal (N) birth weight pigs.Low (L: <10thpercentile; n=6) and normal (N: 40th - 60th percentile; n=12) birth weig...

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Endocrine Abstracts

The influence of changes in macronutrient intake during gestation on gene expression of on glucocorticoid receptor (GR) and 11-beta-hydroxysteroid dehydrogenase 1 and 2 (11βhsd1 and 2) in the livers of neonatal pigs; effect of size at birth

The effect of a high fat, high cholesterol diet on blood glucose in pigs

BiosciAbstracts